Across 110th Street is a 1972 American action-crime film directed by Barry Shear and starring Yaphet Kotto, Anthony Quinn, Anthony Franciosa and Paul Benjamin. The film is set in Harlem, New York and takes its name from 110th Street, the traditional dividing line between Harlem and Central Park that functioned as an informal boundary of race and class in 1970s New York City.

Focusing on a heist, murder and a subsequent investigation, Across 110th Street takes inspiration from both the blaxploitation films of the 1970s as well as the film noir genre. Across 110th Street is remembered in part for its soundtrack, which features a classic song of the same name by Bobby Womack.