Sign Gene: The First Deaf Superheroes is a 2017 superhero film written, produced, directed and starred by Emilio Insolera. The story revolves around a deaf agent, Tom Clerc (played by Insolera), from New York City who is a carrier of a powerful genetic mutation. He is sent to Japan with his colleague, Ken Wong, to investigate crimes believed to have been committed by Japanese deaf mutants. The film's characters, both villains and agents, use sign language as their superhuman powers. The film also stars Carola Insolera, Ben Bahan, Hiroshi Vava, Humberto Insolera and Noboru Kuragawa.

The film makes several references to deaf history, culture, and sign language linguistics. Six languages are spoken and signed in the film: English, Japanese, Italian, American Sign Language, Japanese Sign Language and Italian Sign Language.