The 2010 Hell in a Cell was the second annual Hell in a Cell professional wrestling pay-per-view (PPV) event produced by World Wrestling Entertainment (WWE). It was held for wrestlers from the promotion's Raw and SmackDown brand divisions. The event took place on October 3, 2010, at the American Airlines Center in Dallas, Texas. It was the final Hell in a Cell held during the first brand split, which ended in August 2011, but was reinstated in July 2016.

Six matches were contested at the event. In the main event, Kane retained the World Heavyweight Championship against The Undertaker in a Hell in a Cell match. This made Hell in a Cell 2010 the last WWE pay-per-view in which the World Heavyweight Championship was in the main event until TLC: Tables, Ladders and Chairs (2013). Other matches included Randy Orton retaining the WWE Championship against Sheamus in a Hell in a Cell match, Daniel Bryan retained the United States Championship against The Miz and John Morrison in a Triple Threat Submissions Count Anywhere Match, Wade Barrett defeated John Cena, and Edge defeated Jack Swagger.