The 2010 Elimination Chamber (known as No Way Out in Germany) was the inaugural Elimination Chamber professional wrestling pay-per-view event produced by World Wrestling Entertainment (WWE). It was held for wrestlers from the promotion's Raw and SmackDown brand divisions. It was the first WWE PPV to air following the discontinuation of WWE's ECW brand the week prior. The event took place on Sunday, February 21, 2010, at the Scottrade Center in St. Louis, Missouri. Elimination Chamber replaced WWE's previously annual February event, No Way Out, which had featured the Elimination Chamber match on its last two events. Six matches were aired during the pay-per-view while one dark match occurred prior to the live broadcast.

The concept of the event was that the two main event matches, one each for Raw's WWE Championship and SmackDown's World Heavyweight Championship, respectively, would occur as an Elimination Chamber match. Each match featured six competitors: the defending champion and five challengers. In Raw's Elimination Chamber match, Sheamus defended the WWE Championship against Triple H, Ted DiBiase, Randy Orton, John Cena, and Kofi Kingston, which was won by Cena. In SmackDown's Elimination Chamber match, The Undertaker defended the World Heavyweight Championship against Chris Jericho, John Morrison, Rey Mysterio, CM Punk, and R-Truth, which was won by Jericho. On the undercard, Drew McIntyre retained the WWE Intercontinental Championship against Kane, The Miz retained the WWE United States Championship against Montel Vontavious Porter, and Maryse and Gail Kim competed against LayCool (Layla and Michelle McCool) in an interbrand Divas tag team match.

The event received 285,000 pay-per-view buys, an increase on the figure earned by the 2009 No Way Out pay-per-view. Despite the increased number of buys, the event received generally negative reviews, with reviewers criticizing the undercard of the show as being "weak" and consisting of "filler" material.