The Crime of the Century is an American two-part documentary film, directed, produced, and written by Alex Gibney. The film follows the opioid epidemic in the United States, and the political operatives, government regulations and corporations that enable the abuse of opioids, particularly the Sackler family and Purdue Pharma.

It was aired in two parts beginning on May 10, 2021, and May 11, 2021, by HBO.