Asterix & Obelix: Mission Cleopatra (French: Astérix et Obélix : Mission Cléopâtre) is a 2002 French/German fantasy comedy film written and directed by Alain Chabat and adapted from the comic book series Asterix by René Goscinny and Albert Uderzo. Based on the book Asterix and Cleopatra, which had previously been adapted into a 1968 animated film. A sequel to Asterix and Obelix vs. Caesar (1999), it is the second installment in the Asterix film series.

Christian Clavier and Gérard Depardieu reprise their roles as Asterix and Obelix, alongside newcomers Jamel Debbouze, Monica Bellucci, Claude Rich, Gérard Darmon, Édouard Baer, Dieudonné, and Chabat himself.

It was the most expensive French movie at that time, before being beaten by A Very Long Engagement two years later. A critical success, it was also a major box office success in France, becoming its most successful film in 36 years and second biggest commercial success of all time after 1966's La Grande Vadrouille.