The Ann Sothern Show is an American sitcom starring Ann Sothern that aired on CBS for three seasons from October 6, 1958, to March 30, 1961. Created by Bob Schiller and Bob Weiskopf, the series was the second starring vehicle for Sothern, who had previously starred in Private Secretary, which also aired on CBS from 1953 to 1957.

Sothern portrayed the character Katy O'Connor, the assistant manager of the upscale New York City hotel The Bartley House. Co-stars for the series included Ann Tyrrell, Don Porter and Jesse White who had also co-starred with her in Private Secretary.