First Take is an American sports talk television program on ESPN. Episodes air daily Monday through Friday, with the live episode airing from 10 am ET until noon, with reruns from noon to 2 pm ET on ESPN2 and from 2 to 4 pm ET on ESPNews (when ESPN has other sports programming commitments, ESPN2 will air the live feed in place of ESPN and ESPNEWS will reair the show in place of ESPN2) .

The show broadcast from Studio E at ESPN's headquarters in Bristol, Connecticut for its first eleven years, before the show moved to the network's new South Street Seaport facility on Pier 17 in September 2018 after Labor Day. It also has "roadshow" broadcasts for events such as the weeks of the College Football Playoff, the Super Bowl and the NBA Finals from the cities where those events take place.

The entire show is available as a commercial-free podcast following the broadcast of the recorded show. Clips of the episodes are also uploaded to the ESPN YouTube page for viewing.