Brain Powerd (ブレンパワード, Buren Pawādo) is a Japanese anime television series created by Sunrise. It was directed and written by Gundam creator Yoshiyuki Tomino and features mecha designs by Mamoru Nagano, character designs by Mutsumi Inomata, and music by Yoko Kanno. The 26 episodes of the series originally premiered on the satellite channel WOWOW between April and November 1998. The series was also aired across Japan on the anime network Animax, which also later broadcast the series across its respective networks worldwide, including its English language networks in Southeast Asia and South Asia. Animax aired Bandai Entertainment's localization, the series' English language television premiere. The anime series was licensed by Bandai and distributed across the region on DVD under the title Brain Powered.

The series is set on a future, decimated Earth after the discovery of a mysterious, alien spacecraft dubbed "Orphan". A group of researchers scour the planet for Orphan's disc plates using mecha called "Antibodies" in order to revive the craft, an event that would result in the utter destruction of all lifeforms on Earth. The protagonists Yu Isami and Hime Utsumiya must utilize a special Antibody called "Brain Powerd" to counter the Orphan plans and save humanity.

It was adapted into a manga, with art by Yukiru Sugisaki, which was serialized in Kadokawa Shoten magazine Shōnen Ace and later published in the United States in English by Tokyopop. A series of light novels, music CDs, and other merchandise relating to Brain Powerd also exist.