Lethal Weapon is an American buddy cop action comedy-drama television series developed by Matt Miller and based on the Lethal Weapon film franchise created by Shane Black. The series served as a reboot, which ran for three seasons on Fox, from September 21, 2016 to February 26, 2019.

For its first two seasons, Lethal Weapon starred Clayne Crawford as Martin Riggs and Damon Wayans as Roger Murtaugh, mismatched detective partners who were also the main characters in the films, originally played by Mel Gibson and Danny Glover. The series also includes other characters directly or loosely inspired by characters from the films, including Leo Getz (played by Thomas Lennon), a close friend of Riggs and Murtaugh, portrayed in the films by Joe Pesci.

In May 2018, amidst reports of alleged bad behavior and incidents of hostility between cast and crew on the show's set, Crawford was fired from the show, resulting in the Martin Riggs character being killed off. Seann William Scott was hired to replace him the following season as a new character, Wesley Cole. The third season premiered on September 25.

Wayans left the series following the end-of-season production in December 2018.