Murder in Mississippi is a 1990 American television film which dramatized the last weeks of civil rights activists Michael "Mickey" Schwerner, Andrew Goodman and James Chaney, and the events leading up to their disappearance and subsequent murder during Freedom Summer in 1964. It starred Tom Hulce as Schwerner, Jennifer Grey as his wife Rita, Blair Underwood as Chaney, and Josh Charles as Goodman. Hulce received nominations for Best Actor in a TV Miniseries at the 1990 Golden Globes and 1990 Emmy Awards. The film premiered on February 5, 1990, on NBC.

As a historical docudrama, Murder in Mississippi precedes the storylines of both 1975's Attack on Terror: The FBI vs. the Ku Klux Klan and 1988's Mississippi Burning.

Murder in Mississippi is the title of a 1964 Norman Rockwell painting depicting the same events. The painting is also known as Southern Justice.