Late Night with David Letterman is an American late-night talk show hosted by David Letterman on NBC, the first iteration of the Late Night franchise. It premiered on February 1, 1982, and was produced by Letterman's production company, Space Age Meats, and Carson Productions. Letterman had previously hosted his own morning talk show on NBC from June to October 1980. The show's house band, The World's Most Dangerous Band, was led by music director Paul Shaffer. In 1993, Letterman announced that he would leave NBC to host the Late Show with David Letterman on CBS. The final episode of Late Night was broadcast on June 25, 1993. The series has continued as Late Night with Conan O'Brien, Late Night with Jimmy Fallon and Late Night with Seth Meyers.

In 2013, this series and Late Show with David Letterman were ranked No. 41 on TV Guide's 60 Best Series of All Time. During its run, the show was nominated for the Primetime Emmy Award for Outstanding Variety Series 11 times. It was also nominated for the Primetime Emmy Award for Outstanding Writing for a Variety Series 14 times, winning 4, and won one Primetime Emmy Award for Outstanding Directing for a Variety Series out of 7 nominations.