Mobile Suit Gundam SEED Destiny (Japanese: 機動戦士ガンダムSEED(シード) DESTINY(デスティニー), Hepburn: Kidō Senshi Gandamu Shīdo Desutinī) is an anime television series, a direct sequel to Mobile Suit Gundam SEED by Sunrise and the overall tenth installment in the Gundam franchise. It retains most of the staff from Gundam SEED, including Director Mitsuo Fukuda. Set two years after the original Mobile Suit Gundam SEED, the plot follows the new character Shinn Asuka, a soldier from the Zodiac Alliance of Freedom Treaty, or ZAFT, composed of humans born genetically enhanced labelled as Coordinators. As ZAFT is about to enter into another war against the regular human race, the Naturals, the series focuses on Shinn's as well as various returning characters' involvement in the war. The series spanned 50 episodes, aired in Japan from October 2004 to October 2005, on the Japan News Network television stations Tokyo Broadcasting System and Manichi Broadcasting System.

In December 2005, Sunrise aired a special episode that remade the events from the series' last episode. A series of four films compiling the series has also been released in Japan. Gundam SEED was adapted into various manga adaptations and light novels published by Kodansha and Kadokawa Shoten. Bandai Entertainment licensed the series for North America release, and has published it in DVD volumes. The series also aired on television in Canada, while the compilation films were also released in DVDs. The first manga was licensed and published by Del Rey Manga. Various types of merchandising have also been released, including CD soundtracks and video games. In 2013, a HD remaster of the series was released by Sunrise.

Gundam SEED Destiny became highly popular in Japan, having sold over one million DVD volumes and soundtracks topping charts. The series was also the winner of the Anime Grand Prix in both 2004 and 2005 polls. Critical reception has also been positive with focus on the themes and events occurring throughout the series. However, Gundam SEED Destiny has often been compared with its predecessor for sharing similar situations with the director's cut OVA having helped to improve an ending that was felt to be weak.

A sequel film titled Mobile Suit Gundam SEED Freedom was released in January 2024.