Lie to Me (stylized as Lie to me*) is an American crime drama television series created by Samuel Baum that aired on Fox from January 21, 2009, to January 31, 2011. In the show, Dr. Cal Lightman (Tim Roth) and his colleagues in The Lightman Group accept assignments from third parties (commonly local and federal law enforcement), and assist in investigations, reaching the truth through applied psychology: interpreting microexpressions, through the Facial Action Coding System, and body language. In May 2009, the show was renewed for a second season consisting of 13 episodes; season two premiered on September 28, 2009. On November 24, 2009, Fox ordered an extra nine episodes for season two, bringing the season order to 22 episodes.

On May 12, 2010, Entertainment Weekly reported that Lie to Me received a 13-episode third season pick-up. The third season of Lie to Me was originally set to premiere on November 10, 2010. On September 28, 2010, the date was moved up to October 4, 2010, because of the cancellation of Lone Star. On May 11, 2011, Fox canceled Lie to Me after three seasons.

The show is inspired by the work of Paul Ekman, a specialist on facial expressions and a professor emeritus of psychology at the University of California San Francisco School of Medicine. Ekman has been an advisor to police departments and anti-terrorism groups. He was a scientific consultant in the production of the series. The lead character of Lie to Me, Cal Lightman, is based on Ekman.