McDuff, The Talking Dog was a Saturday morning live action television program that aired on NBC in 1976. The show centered on the ghost of a 100-year-old sheepdog who used to live in the home now owned by a veterinarian, Dr. Calvin Campbell (played by Walter Willison). McDuff (voice provided by Jack Lester) could talk not only to the other animals, but also to Dr. Campbell. However, Dr. Campbell was the only person who could hear or see McDuff, which often led to wacky situations.

Dr. Campbell's neighbor, Amos Ferguson, was played by Gordon Jump.