The Strain is an American horror drama television series that aired on FX from July 13, 2014, to September 17, 2017. It was created by Guillermo del Toro and Chuck Hogan, based on their novel trilogy of the same name. Carlton Cuse served as executive producer and showrunner. Del Toro and Hogan wrote the pilot episode, "Night Zero", which del Toro directed. A thirteen-episode first season was ordered on November 19, 2013. The pilot episode premiered at the ATX Television Festival in Austin, Texas, in early June 2014.

On August 6, 2014, FX renewed The Strain for a 13-episode second season which premiered on July 12, 2015. On August 7, 2015, FX renewed The Strain for a 10-episode third season which premiered on August 28, 2016. FX renewed the series for a fourth and final season on September 27, 2016, which premiered on July 16, 2017. During the course of the series, 46 episodes of The Strain aired over four seasons.

The show centers around Dr. Ephraim Goodweather, the head of the CDC's New York-based Canary Project, who is called upon to investigate an airplane landing wherein everyone aboard is dead. What his team discovers is a viral outbreak that has similarities to an ancient strain of vampirism. The virus begins to spread and Goodweather works with his team and a group of the city's residents to wage a war to save humanity. As the series progresses, Goodweather finds new allies as they discover a dark underworld, political corruption and a sinister plot for dominion over life.