Scream (also known as Scream: The TV Series) is an American anthology slasher television series developed by Jill Blotevogel, Dan Dworkin and Jay Beattie for MTV and Brett Matthews for VH1. It is based on the slasher film series of the same name created by Kevin Williamson and Wes Craven. The series is produced by Dimension Television and MTV Production Development, and was formerly filmed in Louisiana, in locations such as Baton Rouge and New Orleans. Blotevogel and Jaime Paglia originally served as showrunners during the first season before being replaced by Michael Gans and Richard Register in the second season, because of creative differences.

The first two seasons were situated in the fictional town of Lakewood, where a string of murders took place. At the center of those murders was Emma Duval (played by Willa Fitzgerald), a teenage girl who is somehow tied to the town's dark past. The series premiered on MTV on June 30, 2015, and concluded its first season on September 1, 2015. The series was officially picked up for a second season in July 2015. After its second season concluded, a two-hour Halloween special aired in October 2016.

In October 2016, MTV renewed the series for a third and final season. In April 2017, MTV announced that they were rebooting the series with the third season, with a new cast and setting. As part of the reboot process, it was revealed that Brett Matthews would be serving as the main showrunner. In addition, Queen Latifah, Shakim Compere and Yaneley Arty would be added as executive producers for the series under Flavor Unit Entertainment. RJ Cyler, C. J. Wallace, Tyga, Keke Palmer, Jessica Sula, Giorgia Whigham, Giullian Yao Gioiello and Tyler Posey starred in the rebooted third season. In June 2019, it was announced that the series would be moving to VH1 ahead of the premiere of the third season. The third and final season, subtitled Resurrection, premiered on July 8, 2019.