The Knick is an American medical period drama television series on Cinemax created by Jack Amiel and Michael Begler and directed by Steven Soderbergh. The series follows Dr. John W. Thackery (Clive Owen) and the staff at a fictionalized version of the Knickerbocker Hospital (the Knick) in New York during the early twentieth century. Amiel and Begler wrote the majority of the episodes and are executive producers. Owen, Soderbergh, Gregory Jacobs, and Michael Sugar (Anonymous Content) were executive producers. Steven Katz was the supervising producer and also writer, Michael Polaire was the producer and David Kirchner the associate producer.

The show premiered on Cinemax on August 8, 2014. On July 10, 2014, Cinemax renewed The Knick for a ten-episode second season, which premiered on October 16, 2015. In March 2017, Cinemax announced the series was canceled.In September 2020, Soderbergh confirmed that a new season of The Knick was in development led by Barry Jenkins and André Holland, who would return as his character Dr. Algernon C. Edwards, and that original creators Jack Amiel and Michael Begler have written a pilot episode. In April 2023, Begler confirmed that a spin-off series was still in development. The pilot script features Algernon Edwards and is set in 1919 Harlem.