Keeping Up with the Kardashians (often abbreviated KUWTK) is an American reality television series which focused on the personal and professional lives of the Kardashian–Jenner blended family. It aired on the E! network between 2007 and 2021. The series focused mainly on sisters Kim, Kourtney, and Khloé Kardashian and their half-sisters, Kendall and Kylie Jenner. It also featured their parents, Kris and Caitlyn Jenner, and brother, Rob. Partners of the Kardashian sisters also appeared on the show. Its premise originated with Ryan Seacrest, who also served as an executive producer. The series premiered on the E! cable network on October 14, 2007, and ran for 20 seasons over the span of almost fourteen years, becoming one of the longest-running reality television series in the US. The final season premiered on March 18, 2021.

Keeping Up with the Kardashians was universally panned since its premiere. It was often criticized for the high degree of emphasis on the "famous for being famous" concept, and for appearing to fabricate some aspects of its storylines. However, some critics described the series as a "guilty pleasure" and acknowledged the family's success. Despite its negative reviews, Keeping Up with the Kardashians attracted high viewership ratings, becoming one of the network's most successful shows and winning several audience awards. The series' success led additionally to the creation of numerous spin-off series, including: Kourtney and Kim Take Miami, Kourtney and Kim Take New York, Khloé & Lamar, Kourtney and Khloé Take The Hamptons, Dash Dolls, Rob & Chyna, Life of Kylie, and Flip It Like Disick. The network also broadcast several television specials featuring special events involving members of the family and friends.

On September 8, 2020, the family announced via Instagram that the show would end in 2021. The series concluded on June 20, 2021. Nearly a year later, the family returned to reality television for the Hulu series The Kardashians, which premiered on April 14, 2022.