Esme & Roy is an animated children's television series created by Dustin Ferrer and Amy Steinberg. The series is produced by Sesame Street producer Sesame Workshop and Canada-based animation studio Nelvana, in association with Corus Entertainment.

The series focuses on a young girl named Esme and her best friend, a monster named Roy, who care for all kinds of creatures when their regular guardians need aid. Esme and Roy was broadcast simultaneously on HBO in the United States and Treehouse TV in Canada on August 18, 2018. It was the first original show for HBO Family since Classical Baby, but ironically, it also ended up being the final original show for HBO Family at all.

On May 6, 2019, it was announced that the series was renewed for a second season. The show began airing on PBS Kids on August 30, 2019. In September 2019, it was announced new episodes of the show would be moving from HBO to HBO Max (now Max), starting with the second season. The second season premiered on June 25, 2020. A holiday-themed episode was released on December 10, 2020. The second season premiered on PBS Kids on Saturday, March 6, 2021.

The show was removed from HBO Max on August 17, 2022.