The Cyanide & Happiness Show is an American adult animated web and streaming television series created by Kris Wilson, Rob DenBleyker, Matt Melvin, and Dave McElfatrick based on their webcomic Cyanide & Happiness. Each episode consists of a few short stories that have little to no connection to each other (with the exception of six episodes from Season 3, which were a story arc). The creators described the goal of each episode to be "to extract the human excretion known as laughter from your face hole via fast-paced weird comedy."

The Cyanide & Happiness Show was funded through a successful Kickstarter campaign. The first season was initially released on YouTube from November 12, 2014, to January 21, 2015. The show was later acquired by Seeso, which produced second and third seasons before selling the show to VRV in mid-2017. On February 20, 2019, it was announced that VRV had renewed the show for a fourth season, which comprised 10 episodes. Following the closure of VRV, the show has not seen any new seasons or episodes since 2019 with all the episodes being released on Explosm’s YouTube channel.