La Reina del Sur (lit. 'The Queen of the South') is a Spanish-language telenovela based on a novel of the same name by Spanish author Arturo Pérez-Reverte. It premiered on 28 February 2011. The first season is produced by the American television network Telemundo in conjunction with the Antena 3 network and RTI Producciones, while the second and third seasons are co-produced by Telemundo Global Studios and Netflix. The series depicts the rise of Teresa Mendoza (Kate del Castillo), a young woman from Mexico who becomes the most powerful drug trafficker in southern Spain.

With a $10 million budget it is the second most expensive telenovela ever produced by Telemundo, the first being El Señor de los Cielos. An English language remake, Queen of the South, premiered in June 2016 on USA Network, starring Alice Braga.

The series has been renewed for a second season that premiered on 22 April 2019. On 16 July 2020, Telemundo announced that the series was renewed for a third season. The third season aired from 18 October 2022 to 16 January 2023.