Face Off is an American reality television game show program on the SyFy cable network channel in which a group of prosthetic makeup artists compete against each other to create prostheses such as those found in science fiction, fantasy, and horror films. One or more challenges are featured in each episode, with the work reviewed by a panel of judges who eliminate one or more artists each week until a final winner is chosen.

Actress McKenzie Westmore, known for her role as Sheridan Crane on the former NBC/DirecTV soap opera Passions and a member of the Westmore family of makeup artists, serves as the show's host while her father, Michael Westmore, serves as the show's mentor (seasons 4-13). For each assignment, the contestants' work is individually evaluated by a panel of professional special effects makeup artists who serve as judges. These judges have included television and film makeup artist Glenn Hetrick, Academy- and Emmy Award–winning makeup artist Ve Neill, creature designer and director Patrick Tatopoulos (seasons 1-3), and creature and concept designer Neville Page (seasons 3-13). Industry figures and artists including Brian Grazer, Kevin Smith, Paul W. S. Anderson, Greg Nicotero, Rick Baker, Doug Jones, Len Wiseman, Gale Anne Hurd and Marcus Nispel have served as guest judges.

Face Off premiered January 26, 2011 on Syfy. In August 2017, Syfy aired the first season of spin-off series Face Off: Game Face, which brings back four all-stars from previous Face Off seasons for each episode and pits them head-to-head in three rounds for a chance to win US$10,000.