The Hot Zone is an American anthology medical drama television series, based on the 1994 non-fiction book of the same name by Richard Preston and airing on National Geographic.

The first season, consisting of six episodes, aired from May 27 to 29, 2019, and was intended as a miniseries. Largely set in 1989, it follows U.S. Army scientist Nancy Jaax who is confronted with the possibility of a potentially deadly outbreak of Ebola. Jaax, a veterinary pathologist, first identifies the ebolavirus after it appears in monkeys in a Primate Quarantine Facility in the suburbs of Washington, D.C. The season was positively reviewed, and renewed for a second season.

The second season, titled The Hot Zone: Anthrax, focuses on the 2001 anthrax attacks, a week after September 11. The season, also consisting of six episodes, aired from November 28 to 30, 2021.