Mystery! is an anthology television series produced by WGBH Boston for PBS in the United States.

The series was created as a mystery, police and crime drama spin-off of the PBS show Masterpiece Theatre. From 1980 to 2006, Mystery! aired mostly British crime series purchased from or co-produced with the BBC or ITV and adapted from British mystery fiction. In 2002, due to pressure to include more American material, a series based on the novels of US mystery writer Tony Hillerman was produced, but the vast majority of Mystery! programming has always been and continues to be British literary adaptations co-produced with UK-based production companies.

In 2008, PBS combined Mystery! with its predecessor Masterpiece Theatre under the umbrella title Masterpiece, which includes the sub-brands Masterpiece Classic, Masterpiece Mystery!, and Masterpiece Contemporary.