Derry Girls is a British period teen sitcom set in Northern Ireland, created and written by Lisa McGee, that premiered on 4 January 2018 on Channel 4 and ran for three series. The channel's most successful comedy since Father Ted, the series was inspired by McGee's own experiences growing up in Derry, Northern Ireland, in the 1990s, during the final years of the Troubles. It stars Saoirse-Monica Jackson, Louisa Harland, Nicola Coughlan, Jamie-Lee O'Donnell, and Dylan Llewellyn as five teenagers living in mid-1990s Derry while attending Our Lady Immaculate College, a fictional girls' Catholic secondary school based on the real-life Thornhill College, where McGee herself studied. Produced by British production company Hat Trick Productions, Derry Girls was filmed in Northern Ireland, with most scenes shot on location in Derry and some in Belfast.

Although the plot lines of Derry Girls are fictional, the series frequently references actual events of the Troubles and the Northern Ireland peace process, including the 1994 IRA ceasefire announcement, the 1995 visit to Northern Ireland of President Bill Clinton and First Lady Hillary Clinton, and the Good Friday referendum of 1998. Archival footage relating to key political figures such as Ian Paisley, Gerry Adams, Martin McGuinness, John Hume and Mo Mowlam is shown via TV and radio broadcasts in family homes. The soundtrack features popular music of the era, by acts including Ace of Base, Blur, Cypress Hill, Salt-N-Pepa, Enya, the Corrs, Boyzone, Scarlet, Fatboy Slim, PJ & Duncan, and the Cranberries.

The first series, broadcast on Channel 4 in January and February 2018, became the most-watched series in Northern Ireland since modern records began in 2002. The series was renewed shortly after the pilot episode aired, and the second series was broadcast in March and April 2019. A third and final series set in 1996 and 1997 was commissioned for 2020, although filming was delayed due to the COVID-19 pandemic impact on television production, and premiered in April 2022. A final special extended 45-minute episode titled "The Agreement", set in 1998 during the signing of the Good Friday Agreement, aired on 18 May 2022.

Derry Girls has inspired a mural of its main characters painted on the side of Badgers Bar and Restaurant at 18 Orchard Street, Derry, which has become a popular tourist attraction.