Cuidado con el ángel (English title: Don't Mess with an Angel; lit. Be Careful with the Angel) is a Mexican telenovela produced by Nathalie Lartilleux for Televisa in 2008. It is an adaptation of the Venezuelan telenovela, Una muchacha llamada Milagros produced in 1974 by Venevisión. Each episode garnered nearly 5 million viewers daily.

On June 9, 2008, Canal de las Estrellas started broadcasting Cuidado con el ángel weekdays at 4:00pm, replacing Al diablo con los guapos. The last episode was broadcast on March 6, 2009 with Atrévete a soñar replacing it.

On July 6, 2009, ABS-CBN started broadcasting in the Philippines as Maria de Jesus: Ang Anghel sa Lansangan weekdays at 3:30pm (then moved to 4:00pm and later 4:15pm). The last episode was broadcast on April 9, 2010.

Univision started broadcasting Cuidado con el ángel on September 22, 2008 weeknights at 8pm/7c, replacing Al diablo con los guapos. The last episode was broadcast on July 6, 2009 with En nombre del amor replacing it on July 7, 2009. Univision reruns Cuidado con el ángel from October 22, 2012 to July 19, 2013 replacing Sortilegio weekdays at 2pm/1c. The last episode was broadcast on July 19, 2013 with Cachito de cielo replacing it on July 22, 2013.

Maite Perroni and William Levy starred as protagonists.

Ana Patricia Rojo, Arturo Carmona, Rocío Banquells, Laura Zapata, Nailea Norvind, and Michelle Vieth starred as antagonists.

The leading actors Helena Rojo, Ricardo Blume, and Evita Muñoz "Chachita" starred as stellar performances.