Wild West C.O.W.-Boys of Moo Mesa is a 1992 American animated television series created by comic book artist Ryan Brown, known for his work on Teenage Mutant Ninja Turtles. It aired as part of ABC's Saturday morning lineup.

It was produced by Greengrass Productions in association with King World Productions, and was animated by Gunther-Wahl Productions for its first season and Ruby-Spears Enterprises for its second. At the time of launch, it was the second animated series involving King World Productions to be broadcast (the other was the animated spin-off of The Little Rascals, which aired on ABC from 1982 to 1984).

First broadcast on September 12, 1992, the show ran for two seasons of thirteen episodes each.