Take My Wife is an American sitcom on the Seeso comedy subscription streaming service. The show follows former real-life couple Cameron Esposito and River Butcher as they share their lives as stand-up comics who are balancing work, relationships, and the breaking down of gender barriers. On December 19, 2016, Seeso renewed the series for a second season. On August 9, 2017, Seeso announced the shutdown of its service by the end of the year, leaving Take My Wife without a home. On March 5, 2018, it was announced that season 1 and the previously unaired season 2 were now available on iTunes (US) and would be available on the Starz app starting May 1, 2018. Take My Wife is also now available on iTunes in the UK (as of April 30, 2018).

For its second season, the show's creators and producers featured large numbers of women, people of color, and LGBTQ individuals in front of and behind the camera. Esposito has acknowledged this was a conscious effort on their part: "As a small budget show, we prioritized hiring queer folks, POC, and female standups."