3 lbs (pronounced "three pounds") is an American medical drama television series created by Peter Ocko, that aired on CBS from November 14, 2006 to November 7, 2008, replacing the cancelled series Smith. The show itself was then canceled three weeks later due to poor ratings.

The title refers to the fact that the average human brain weighs approximately three pounds. The show follows the medical careers of prominent brain surgeon Doctor Douglas Hanson (played by Stanley Tucci) and his protégé, Jonathan Seger.

The show was promoted as "the next great medical drama." The theme song is "Calling All Angels" by Train. Eight episodes were made, and the five episodes that did not originally air in the United States are available on Amazon Prime.

The original pilot was filmed with Dylan McDermott as Dr. Doug Hanson and Reiko Aylesworth as Dr. Adrienne Holland. When that pilot went unsold, it was discarded and the roles were recast. The series then filmed in New York City, at the request of Tucci, who did not want to be away from home during production.