Game Over was a short-lived American adult computer-animated sitcom created by David Sacks (who later became president of Nickelodeon Animation Studio), and produced by Carsey-Werner Productions. The series was broadcast on UPN in 2004. It was cancelled after five episodes.

Game Over (the title was inspired by the phrase "game over" that commonly concludes video games) focused on what happens to video game characters after the game ends. It recounted the lives of the Smashenburns, a far-from-ordinary suburban family that lived in an alternate video game universe.

The show made numerous references to video games and even featured certain game characters as cameos. For example, Crash Bandicoot appears on a Got Milk? billboard, and creatures from Oddworld: Abe's Oddysee appear in one of the episodes.

Marisa Tomei voiced the character of Raquel Smashenburn in the series' unaired pilot episode, but scheduling problems saw Lucy Liu take over the role for the actual series.Game Over was heavily hyped by UPN before its debut. It generally received positive press on its airing. Despite this, only six episodes were made, which aired on a variety of different days – the fourth and fifth episodes were broadcast on April 2, 2004, and the sixth episode ("Monkey Dearest") was not aired.