Game Over is an American adult animated sitcom created by David Sacks and produced by Carsey-Werner Productions. The series was broadcast on UPN in 2004, and was cancelled after five episodes. It was animated using computer animation.

Game Over (the title was inspired by the phrase "game over" that commonly concludes video games) focuses on what happens to video game characters after the game ends, and recounted the lives of the Smashenburns, a far-from-ordinary suburban family that lived in an alternate video game universe. The show made numerous references to video games and even featured certain game characters as cameos. For example, Crash Bandicoot appears on a Got Milk? billboard, and creatures from Oddworld: Abe's Oddysee appear in one of the episodes.

Marisa Tomei voiced the character of Raquel Smashenburn in the series' unaired pilot episode, but scheduling problems saw Lucy Liu take over the role for the actual series.

Game Over was heavily hyped by UPN before its debut. It generally received positive press on its airing. Because of this, six episodes were produced and aired on a variety of different days – the fourth and fifth episodes were broadcast on April 2, 2004, with the sixth episode ("Monkey Dearest") never aired and only appears on the complete series DVD.