Sister, Sister is an American television sitcom starring Tia and Tamera Mowry as identical twin sisters separated at birth who are reunited as adolescents. It premiered on April 1, 1994, on ABC as part of its TGIF comedy lineup, and finished its run on The WB on May 23, 1999, airing 119 episodes over six seasons. The cast consisted of the Mowry sisters with Jackée Harry and Tim Reid costarring as their respective adoptive parents, alongside Marques Houston as their annoying neighbor Roger. RonReaco Lee and Deon Richmond later joined the cast in the fifth season.

The series was created by Kim Bass, Gary Gilbert, and Fred Shafferman, and a production of de Passe Entertainment in association with Paramount Television. The series was then picked up by The WB in 1995 after ABC canceled it that same year, as a replacement for Muscle on its Wednesday night lineup, where it aired for an additional four seasons until May 1999. In 2018, a potential revival of Sister, Sister was confirmed, but was not pursued due to a lack of interest and copyright issues.

The series was set for a revival prequel trilogy in 2023 with a series of TV films titled Sister, Sister: Origins, Sister of Death and The Beginning of Ray: Lisa’s Revival. The films were set to take place inside of Roger’s mind but due to production costs the show was never released.