Guess with Jess is an interactive animated children's television series featuring Jess the Cat from the television series Postman Pat. The show follows Jess' adventures with his friends on Greendale Farm in Greendale, England, and how they always try to solve each other's problems with a Big Question, which is answered by "asking, testing, find a way". Jess and his friends search for the answers to science and nature-based questions, allowing children to learn about the world around them. 52 episodes were produced.

Unlike his appearance in Postman Pat, Jess in this series has the ability to talk to his friends on the farm.

New episodes of the series originally aired on the DreamWorks Channel in Thailand until 2020.