Painkiller Jane is a television series based on the comic book character of the same name. Airing on the Sci Fi Channel in the US starting April 13, 2007 and Global in Canada, it starred Kristanna Loken as the title character. The show was canceled after one season of 22 episodes.

The television series focuses on an agent of the Drug Enforcement Administration (DEA) who discovers that she has superhuman abilities which revive her after her apparent death. She is recruited by agents of a covert government agency which is tasked with identifying and neutralizing human mutants with mental powers.