Ben 10: Ultimate Alien is an American animated television series created by the team Man of Action, produced by Cartoon Network Studios, and distributed by Warner Bros. Domestic Television. It is the direct sequel to Ben 10: Alien Force (2008–2010), serving as the third series in the Ben 10 franchise. The series premiered on April 23, 2010, on Cartoon Network in the US. In India and Latin America, it premiered on October 10, 2010. In Canada, the series started airing on September 12, 2010, on Teletoon.

The series finale aired on March 31, 2012, with the two-part episode "The Ultimate Enemy" dedicated to the memory of series developer, writer, and producer Dwayne McDuffie, who died during the production of the series. A sequel series, Ben 10: Omniverse, premiered in August 2012.