Sex Change Hospital is an American documentary-style reality television series about 12 transgender people who have sex reassignment surgery at the Mt. San Rafael Hospital in Trinidad, Colorado, under the care of OB/GYN Marci Bowers. The patients talk about their lives and viewers follow them through their consultations with Bowers, the surgical procedures, and their post-surgical experience.

Sex Change Hospital was produced by World of Wonder, and premiered in the United Kingdom on More4 in May 2007. In June, a 47-minute excerpt screened at the 31st Frameline Film Festival in San Francisco. After the series aired on US specialty channel WE tv in 2008, it was nominated for a GLAAD Media Award for Outstanding Documentary. Discovery Health rebroadcast the series in the US in 2009, and again in 2011 when it relaunched as Discovery Fit & Health.

Bowers was the subject of the 2008 documentary Trinidad; she and her practice also feature in the final episode of TransGeneration, a documentary-style reality series that aired in 2005.