East West 101 is an Australian drama series airing on the SBS network. The series was produced and created by Steven Knapman and Kris Wyld, the team behind other drama series such as Wildside and White Collar Blue. It ran from 2007–2011, having three series.

East West 101 is set around the Major Crime Squad in metropolitan Sydney. It was based upon the experiences of actual detectives in a crime unit in Sydney's western suburbs. It was filmed on location, in Sydney suburbs such as Auburn, Bankstown, Redfern, Chinatown and Maroubra.

The series was made by SBS with the Film Finance Corporation of Australia and the New South Wales Film and Television Office. It has been sold to Israel and other countries in the Middle East. The second season finished airing on 24 November 2009, and a third season was announced and filmed in 2010. It began airing on SBS One on 20 April 2011. The DVD of the third season was released on 4 May 2011.