Dune: Prophecy is an American science fiction television series developed by Diane Ademu-John and Alison Schapker for HBO. Set in Frank Herbert's Dune universe, the series focuses on the origins of the Bene Gesserit, a powerful social, religious, and political force whose members possess superhuman powers and abilities after undergoing years of intense physical and mental conditioning. Dune: Prophecy is a prequel to the Denis Villeneuve films Dune and Dune: Part Two, taking place some 10,000 years earlier. It draws upon, but is set after, the Great Schools of Dune novel trilogy (2012–2016) by Brian Herbert and Kevin J. Anderson. The show is produced by Legendary Television, with Schapker serving as showrunner, writer, and executive producer.

During Legendary Entertainment's 2016 acquisition of the television and film rights to the Dune book series, it began development of a two-part film adaptation with Denis Villeneuve serving as director by 2017. Legendary Television ordered the series in 2019 as a spin-off project from Villeneuve's films. Various creative figures joined by 2019, and following creative overhauls, Schapker became the show-runner with Anna Foerster as director for multiple episodes by June 2023. Meanwhile, casting took place from November 2022 to June 2023. Principal photography began in November 2022 in Budapest and Jordan, and wrapped in December 2023.

The first season of Dune: Prophecy premiered to mostly positive reviews on November 17, 2024. The series was renewed for a second season in December 2024.