Amrutham (lit. 'Elixir') was an Indian Telugu-language television sitcom created and produced by Gunnam Gangaraju. The show originally aired on Gemini TV from 18 November 2001 to 18 November 2007, running for six years with a total of 313 episodes. It is widely regarded as the greatest Telugu comedy TV series of all time. The show, known for its clean and family-friendly humour, satirized a wide range of topics, including soap operas, films, competitive exams, superstitions, game shows, and politics.

The show centers on four characters: Amrutha Rao and Anjaneyulu (Gundu Hanumantha Rao), childhood friends who own the Amrutha Vilas restaurant in Hyderabad; Sarvam (Vasu Inturi), a cook and server from Tamil Nadu who works for them; and their greedy landlord, Appaji (Sivannarayana), who frequently imposes unfair penalties. Amrutha Rao and Anjaneyulu often come up with quirky ideas to grow their business, but always end up failing in amusing ways. The role of Amrutha Rao was first played by Sivaji Raja, then Naresh, and ultimately by Harsha Vardhan, who appeared in over 200 of the show's 313 episodes.

Most episodes were written by Gunnam Gangaraju, along with Vasu Inturi, who also portrayed Sarvam. The show's title song was composed and sung by Kalyani Malik, with lyrics by Sirivennela Sitarama Sastry. Several notable film technicians, such as director Chandra Sekhar Yeleti, cinematographer K. K. Senthil Kumar, production designer S. Ravinder, and music composer Kalyani Malik worked on the show in the early stages of their careers.

Amrutham originally aired every Sunday at 8 PM on Gemini TV. In the early 2000s, when Telugu television was dominated by melodramatic soap operas, Amrutham was hailed as a "phenomenon" and a "sensation," breaking the norm and becoming one of the most successful Telugu shows of all time. Though the series ended at its peak due to a lack of new ideas and writers, it has been re-telecasted multiple times, consistently drawing high ratings. ZEE5 now holds its digital rights. A spin-off film, Amrutham Chandamamalo, was released in 2014, and a sequel series, Amrutham Dhvitheeyam, streamed on ZEE5 from 2020 to 2021.