Best of Luck Nikki is an Indian sitcom that originally aired on Disney Channel from 3 April 2011 to 16 April 2016. The series is the official Indian adaptation of the American series Good Luck Charlie, with a similar plot.

The series was created by Phil Baker and Drew Vaupen, who aimed to develop a program that would appeal to all family members, not just children and teens. The episodes revolve around the Singh family as they adjust to the birth of their fourth child, Nikki. In each episode, Dolly Singh, the older sister, creates a video diary with advice for Nikki on navigating their family and life as a teenager.

In the third season of the show, Nikki's younger sibling, Bobby, is born. In the fourth season, Himani becomes pregnant again and gives birth to a child named Kritika.