Best of Luck Nikki is an Indian sitcom that originally aired on Disney Channel India from April 3, 2011, to April 16, 2016. The series is an adaptation of the American series Good Luck Charlie, with a similar plot.

The series was created by Phil Baker and Drew Vaupen, who aimed to create a program that would appeal to all family members rather than simply to children and teens. The episodes revolve around the Singh family as they try to adjust to the birth of their fourth child Nikki. In each episode, Dolly Singh, the character of the older sister, creates a video diary containing advice for Nikki about surviving their family and life as a teenager.

In the third season of the show, Nikki's younger sibling Bobby is born. In the fourth season, Himani is again pregnant with a child named Kritika.