Melissa Suzanne George (born 6 August 1976) is an Australian-American actress and entrepreneur. A former national rollerskating champion and model, George began her acting career playing Angel Parrish on the Australian soap opera Home and Away (1993–96). After moving to the United States, George made her feature film debut in Dark City (1998). She later had supporting roles in Steven Soderbergh's The Limey (1999), David Lynch's Mulholland Drive (2001), Sugar & Spice (2001), and Down with Love (2003).

George made the transition to leading roles when she appeared as Kathy Lutz in the 2005 remake of The Amityville Horror. She followed this with a succession of films in the thriller and horror genres, such as Derailed (2005), Turistas (2006), WΔZ (2007), 30 Days of Night (2007), Triangle (2009), A Lonely Place to Die (2011), and Felony (2013).

On television, George has had recurring roles on Alias (2003–04), Grey's Anatomy (2008–09) and The Good Wife (2013–14), and a starring role on the NBC medical drama Heartbeat (2016). She received a Golden Globe nomination for her portrayal of Laura Hill on HBO's In Treatment (2008). In 2010, she appeared as Clara Musso on the FOX crime drama series Lie to Me*. She also starred in the Australian miniseries The Slap (2011), for which she received a Logie Award, and in the BBC spy series Hunted (2012). In 2015, she appeared in the American adaptation of The Slap, playing the same character, Rosie, that she played in the previous version. In 2018 she starred as Diane Hagerty on Hulu's The First. She currently plays Margot on the Apple TV+ drama series The Mosquito Coast (2021).