The Brain Game is a weekly quiz bowl show for high school students that airs on NBC-affiliate WTHR-13 in Indianapolis, Indiana. Originally called Exercise in Knowledge when introduced in 1972 (under the station's prior call letters, WLWI), the Brain Game is currently broadcast at 7 pm on Saturdays, and is hosted by WTHR morning meteorologist Chuck Lofton. It is sponsored by Westfield Insurance, which also sponsors four other high school quiz shows. The show is filmed at the WTHR studios on Meridian Street in Indianapolis. The Brain Game has been filmed in HD since 2008.

Chuck Lofton has hosted the Brain Game since 2013, taking over for meteorologist Chris Wright who hosted from 2000 to 2013. Bob Gregory hosted for 28 years, from the show's start in 1972 until 2000. Until 2008 the show was filmed at the Fairbanks Center at Butler University.

The Brain Game was nominated for a Regional Emmy in 2001 for best On Camera Talent - Non News, in 2003 for best Children/Youth Program - Regularly Scheduled, in 2004 for best Children/Youth Program - Regularly Scheduled, and in 2007 for best Children/Youth Program.Due to renovations at the WTHR-13 TV station, the 2017-18 Brain Game season will be on hiatus. The Westfield Insurance group has pulled sponsorship of the contest.