CSI: Vegas (Crime Scene Investigation: Vegas) is an American crime drama series that aired on CBS on October 6, 2021. It is a revival of the 2000–15 series CSI: Crime Scene Investigation and the fifth and final series in the CSI franchise. The series stars Paula Newsome, Matt Lauria, Mandeep Dhillon, and Mel Rodriguez as new characters. William Petersen and Jorja Fox reprised their roles from CSI: Crime Scene Investigation as Gil Grissom and Sara Sidle during the first season before departing, while Marg Helgenberger reprises her CSI: Crime Scene Investigation role as Catherine Willows beginning with season two. Wallace Langham, Paul Guilfoyle and Eric Szmanda also reprise their roles as David Hodges, Jim Brass and Greg Sanders, in a guest capacity.

Originally branded as an epilogue limited series, the show was renewed for a second season in December 2021, without Fox, Petersen, or Rodriguez returning. The first season consisted of ten episodes. The second season premiered on September 29, 2022, consisting of 21 episodes. On February 21, 2023, CBS renewed CSI: Vegas for a shortened third season, consisting of ten episodes.

On November 13, 2023, CBS announced the premiere date for its shows. The third season premiered on February 18, 2024, moving to Sunday nights. In April 2024, the series was canceled after three seasons. The series finale aired on May 19, 2024.