The Apprentice: ONE Championship Edition is a reality television program that premiered in Asia on 18 March 2021 and concluded on 10 June 2021. On 3 December 2021, the show won two major categories at the 2021 Asian Academy Creative Awards for Best Non-Scripted Entertainment and Best Adaptation of an Existing Format. It began broadcasting worldwide in June 2021. Although the series was filmed in Asia, it has no relation to The Apprentice Asia, and it is the first-ever global edition of The Apprentice co-owned by MGM and ONE Championship. On 1 February 2022, it became the first version of the franchise to stream on Netflix in over 150 countries.

The show features 16 candidates from around the world competing in both business and physical challenges. CEOs from major companies and prominent mixed martial artists will also guest star on the show. The finale is won by Venezuelan sales director Jessica Ramella, who won a US$250,000 job offer to work directly under ONE Chairman and CEO Chatri Sityodtong for a year as his protégé (and as a member of chief of staff) in Singapore.

On 21 June 2021, Sityodtong greenlit a second season of the show, expecting newer challengers.