The Twisted Whiskers Show is an animated comedy television series based on the Twisted Whiskers greeting cards created by Terrill Bohlar for American Greetings. The series was produced by American Greetings Properties (and its related company CloudCo, Inc.), Telegael, DQ Entertainment and MoonScoop LLC.

The Twisted Whiskers Show first began airing on CBBC in the UK, on September 26, 2009. Since then, it has later premiered internationally (on Teletoon in Canada, on MTV3 Junior in Finland, on Disney Channel in Japan and on Cartoon Network in Latin America) until it first aired in the US on October 10, 2010 on the Hasbro/Discovery TV network, Discovery Family (formerly known as The Hub until October 13, 2014) as the first program of said network. The series finale aired on March 1, 2010. 52 episodes were aired and produced.