The Paul O'Grady Show was a British comedy chat show presented by comedian Paul O'Grady, first shown on 11 October 2004. The programme was a teatime chat show consisting of a mixture of celebrity guests, comic stunts, musical performances, and occasionally viewer competitions.

The format was originally devised by Granada Television and was broadcast on ITV until December 2005, before moving to Channel 4 in 2006, where the show was produced by Olga TV. The show originally ended in 2009 when O'Grady announced a move back to ITV, adapting his format to prime-time for Friday nights at 9pm, hosting Paul O'Grady Live from 2010. However the show underperformed in the ratings, averaging just over 3 million viewers, and ended after two series in 2011 amongst reports O'Grady was "keen to move on".

Three years later, the original teatime format returned to ITV on 11 November 2013, airing at its traditional time of weekdays at 5pm. It concluded its twelfth run on 13 December 2013. It returned for a thirteenth series on 28 April 2014, which ended on 30 May 2014. The programme has averaged 2 million viewers in its 5pm slot. A third and final revived series began airing on 20 April 2015 on ITV and ended on 29 May 2015.