Wildlife SOS is a British TV show which was presented by conservationist Simon Cowell. The show was created for Channel 5, and appeared on Animal Planet and the Discovery Channel. It is based in the UK's Wildlife Aid in Leatherhead, Surrey.

In 2014, the first made-for-web episodes of Wildlife SOS started to appear online, made by the Wildlife Aid Foundation. Throughout Wildlife SOS, in addition to 'special' episodes filmed at wildlife centres on the world, the main focus of the series has been on the work of staff and volunteers at the WAF wildlife centre in Surrey.

Wildlife SOS was produced by Wild Productions. Five million people watched the show in 2009. The show's final season aired from 7 April 2013 to 12 May 2013. To produce 6.5 hours of the show that aired in 1999, the producers spent a full year and filmed for 200 hours.