PoliticsNation with Al Sharpton is an American political talk show broadcast on MSNBC, hosted by Al Sharpton. It began on August 29, 2011, on MSNBC's weekday 6 PM slot, the first time that the slot had been occupied by a branded series since January 2011.

In August 2015, it was announced that the series would move to just once a week on Sundays at 8AM starting on October 4, 2015. The series aired its final weekday episode on September 4, 2015. In October, 2020, PoliticsNation was rescheduled to Saturdays and Sundays, airing at 5:00 p.m. Eastern Time both days.