Tic-Tac-Dough is an American television game show based on the paper-and-pencil game of tic-tac-toe. Contestants answer trivia questions to put up their respective symbol, X or O, on a tic-tac-toe board. Three versions were produced: the initial 1956–59 run on NBC, a 1978–86 run initially on CBS and then in syndication, and a syndicated run in 1990. The show was produced by Barry & Enright Productions. However, the rights to the format are controlled by NBCUniversal.

Jack Barry, the co-producer, was the original host of the 1950s version, followed by Gene Rayburn and then Bill Wendell, with Jay Jackson and Win Elliot hosting prime time adaptations as well. Wink Martindale hosted the network and syndicated version beginning in 1978, but left the program to host and co-produce Headline Chasers and was replaced by Jim Caldwell for the 1985–86 season. Patrick Wayne hosted the 1990 version. In April 2024, Game Show Network announced another revival, to be hosted by Brooke Burns.