The Powerpuff Girls is an American animated superhero action television series developed by Nick Jennings and Bob Boyle. It is both a reboot and a spin-off series of the Cartoon Network series of the same name created by Craig McCracken. It follows Blossom, Bubbles, and Buttercup, a trio of superpowered girls living in the city of Townsville who are frequently called upon by the townsfolk to protect its residents from evil. The girls were created in a lab by the scientist Professor Utonium, who sought to create the perfect little girls by using sugar, spice, and everything nice along with the accidental addition of the ingredient Chemical X, the source of the girls' superpowers.

It was first announced on June 16, 2014. A year later, it was announced that it would feature new voice actors for the main characters. The series premiered on April 4, 2016, in the United States and Canada, April 21, 2016, in Italy, and April 23, 2016, in Germany. The series ended on June 16, 2019, lasting for three years.